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1

Design, Pharmacology, and NMR Structure of a Minimized Cystine Knot with Agouti-Related Protein Activity †

Jackson, Pilgrim J., McNulty, Joseph C., Yang, Ying-Kui, Thompson, Darren A., Chai, Biaoxin, Gantz, Ira, Barsh, Gregory S., Millhauser, Glenn L.

Journal:

Year:

2002

Language:

english

File:

PDF, 182 KB

english, 2002

2

Effect of NPY5R Antagonist MK-0557 on Weight Regain after Very-low-calorie Diet-induced Weight Loss

Ngozi Erondu, Thomas Wadden, Ira Gantz, Bret Musser, Allison Martin Nguyen, Harold Bays, George Bray, Patrick M. O'Neil, Arnaud Basdevant, Keith D. Kaufman, Steven B. Heymsfield, John M. Amatruda

Journal:

Year:

2007

Language:

english

File:

PDF, 162 KB

english, 2007

3

Cloning and Chromosomal Localization of a Gene (GPR18) Encoding a Novel Seven Transmembrane Receptor Highly Expressed in Spleen and Testis

Ira Gantz, Akira Muraoka, Ying-Kui Yang, Linda C. Samuelson, Ellen M. Zimmerman, Helen Cook, Tadataka Yamada

Journal:

Year:

1997

Language:

english

File:

PDF, 868 KB

english, 1997

4

Structures of the Agouti Signaling Protein

Joseph C. McNulty, Pilgrim J. Jackson, Darren A. Thompson, Biaoxin Chai, Ira Gantz, Gregory S. Barsh, Philip E. Dawson, Glenn L. Millhauser

Journal:

Journal of Molecular Biology

Year:

2005

Language:

english

File:

PDF, 572 KB

english, 2005

5

Discovery of Prototype Peptidomimetic Agonists at the Human Melanocortin Receptors MC1R and MC4R

Haskell-Luevano, Carrie, Hendrata, Siska, North, Cheryl, Sawyer, Tomi K., Hadley, Mac E., Hruby, Victor J., Dickinson, Chris, Gantz, Ira

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 214 KB

english, 1997

6

Molecular Determinants of Ligand Binding to the Human Melanocortin-4 Receptor †

Yang, Ying-kui, Fong, Tung M., Dickinson, Chris J., Mao, Cheri, Li, Ji-Yao, Tota, Michael R., Mosley, Ralph, Van der Ploeg, Lex H. T., Gantz, Ira

Journal:

Year:

2000

Language:

english

File:

PDF, 171 KB

english, 2000

7

Biological and Conformational Examination of Stereochemical Modifications Using the Template Melanotropin Peptide, Ac-Nle-c[Asp-His-Phe-Arg-Trp- Ala-Lys]-NH 2 , on Human Melanocortin Receptors

Haskell-Luevano, Carrie, Nikiforovich, Gregory, Sharma, Shubh D., Yang, Ying-Kui, Dickinson, Chris, Hruby, Victor J., Gantz, Ira

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 332 KB

english, 1997

8

Randomized clinical trial comparing the efficacy and safety of treatment with the once-weekly dipeptidyl peptidase-4 (DPP-4) inhibitor omarigliptin or the once-daily DPP-4 inhibitor sitagliptin in patients with type 2 diabetes inadequately controlled on m

Goldenberg, Ronald, Gantz, Ira, Andryuk, Paula J., O'Neill, Edward A., Kaufman, Keith D., Lai, Eseng, Wang, Yin Na, Suryawanshi, Shailaja, Engel, Samuel S.

Journal:

Diabetes, Obesity and Metabolism

Year:

2017

Language:

english

File:

PDF, 506 KB

english, 2017

9

A randomized, double-blind, non-inferiority trial evaluating the efficacy and safety of omarigliptin, a once-weekly DPP-4 inhibitor, or glimepiride in patients with type 2 diabetes inadequately controlled on metformin monotherapy

Handelsman, Yehuda, Lauring, Brett, Gantz, Ira, Iredale, Carol, O'Neill, Edward A., Wei, Ziwen, Suryawanshi, Shailaja, Kaufman, Keith D., Engel, Samuel S., Lai, Eseng

Journal:

Current Medical Research and Opinion

Year:

2017

Language:

english

File:

PDF, 1.09 MB

english, 2017

10

Randomized, controlled, double-blind trial of taranabant for smoking cessation

Mary F. Morrison, Paulette Ceesay, Ira Gantz, Keith D. Kaufman, Christopher R. Lines

Journal:

Psychopharmacology

Year:

2010

Language:

english

File:

PDF, 171 KB

english, 2010

11

Peptoid mimics of agouti related protein

Darren A. Thompson, Biao-Xin Chai, Hilary L.E. Rood, Michael A. Siani, Nicholai R. Douglas, Ira Gantz, Glenn L. Millhauser

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 211 KB

english, 2003

12

Loops and Links: Structural Insights into the Remarkable Function of the Agouti-Related Protein

GLENN L. MILLHAUSER, JOE C. McNULTY, PILGRIM J. JACKSON, DARREN A. THOMPSON, GREGORY S. BARSH, IRA GANTZ

Journal:

Annals of the New York Academy of Sciences

Year:

2003

File:

PDF, 4.02 MB

2003

13

Fat and Energy Partitioning: Longitudinal Observations in Leptin-treated Adults Homozygous for a Lep Mutation

Steven B. Heymsfield, Tung M. Fong, Ira Gantz, Ngozi Erondu

Journal:

Year:

2006

Language:

english

File:

PDF, 199 KB

english, 2006

14

NPY5R Antagonism Does Not Augment the Weight Loss Efficacy of Orlistat or Sibutramine

Ngozi Erondu, Carol Addy, Kaifeng Lu, Madhuja Mallick, Bret Musser, Ira Gantz, Joseph Proietto, Arne Astrup, Søren Toubro, Aila M. Rissannen, Serena Tonstad, William G. Haynes, Keith M. Gottesdiener,

Journal:

Year:

2007

Language:

english

File:

PDF, 609 KB

english, 2007

15

A Randomized Trial of Lifestyle Modification and Taranabant for Maintaining Weight Loss Achieved With a Low-Calorie Diet

Thomas A. Wadden, Ken Fujioka, Soren Toubro, Ira Gantz, Ngozi E. Erondu, Menghui Chen, Shailaja Suryawanshi, Wendy Carofano, Amy O. Johnson-Levonas, Deborah R. Shapiro, Keith D. Kaufman, Steven B. Hey

Journal:

Year:

2010

Language:

english

File:

PDF, 213 KB

english, 2010

16

Development of a Population Pharmacokinetic Model for Taranabant, a Cannibinoid-1 Receptor Inverse Agonist

Xiujiang (Susie) Li, Jace Nielsen, Brenda Cirincione, Hankun Li, Carol Addy, John Wagner, Alan Hartford, Ngozi Erondu, Ira Gantz, Jerry Morgan, Julie Stone

Journal:

The AAPS Journal

Year:

2010

Language:

english

File:

PDF, 280 KB

english, 2010

17

Localization of the Genes Encoding the Melanocortin-2 (Adrenocorticotropic Hormone) and Melanocortin-3 Receptors to Chromosomes 18p11.2 and 20q13.2-q13.3 by Fluorescence in Situ Hybridization

Ira Gantz, Takao Tashiro, Christine Barcroft, Yoshitaka Konda, Yoshimasa Shimoto, Hiroto Miwa, Thomas Glover, Gerd Munzert, Tadataka Yamada

Journal:

Year:

1993

File:

PDF, 165 KB

1993

18

Mapping of the Gene Encoding the Melanocortin-1 (α-Melanocyte Stimulating Hormone) Receptor (MC1R) to Human Chromosome 16q24.3 by Fluorescence in Situ Hybridization

Ira Gantz, Tadataka Yamada, Takao Tashiro, Yoshitaka Konda, Yoshimasa Shimoto, Hiroto Miwa, Jeffrey M. Trent

Journal:

Year:

1994

File:

PDF, 132 KB

1994

19

Molecular cloning of the human histamine H2 receptor

Ira Gantz, Gerd Munzert, Takao Tashiro, Matthias Schäffer, Lidong Wang, John DelValle, Tadataka Yamada

Journal:

Biochemical and Biophysical Research Communications

Year:

1991

Language:

english

File:

PDF, 722 KB

english, 1991

20

Neuropeptide Y5 receptor antagonism does not induce clinically meaningful weight loss in overweight and obese adults

Ngozi Erondu, Ira Gantz, Bret Musser, Shailaja Suryawanshi, Madhuja Mallick, Carol Addy, Josee Cote, George Bray, Ken Fujioka, Harold Bays, Priscilla Hollander, Sandra M. Sanabria-Bohórquez, WaiSi Eng

Journal:

Cell Metabolism

Year:

2006

Language:

english

File:

PDF, 270 KB

english, 2006

21

The Acyclic CB1R Inverse Agonist Taranabant Mediates Weight Loss by Increasing Energy Expenditure and Decreasing Caloric Intake

Carol Addy, Hamish Wright, Koen Van Laere, Ira Gantz, Ngozi Erondu, Bret J. Musser, Kaifeng Lu, Jinyu Yuan, Sandra M. Sanabria-Bohórquez, Aubrey Stoch, Cathy Stevens, Tung M. Fong, Inge De Lepeleire,

Journal:

Cell Metabolism

Year:

2008

Language:

english

File:

PDF, 843 KB

english, 2008

22

Chimeras of the agouti-related protein: Insights into agonist and antagonist selectivity of melanocortin receptors

Pilgrim J. Jackson, Bin Yu, Benjamin Hunrichs, Darren A. Thompson, Biaoxin Chai, Ira Gantz, Glenn L. Millhauser

Journal:

Year:

2005

Language:

english

File:

PDF, 680 KB

english, 2005

23

NMR structure of a minimized human agouti related protein prepared by total chemical synthesis

Kimberly A. Bolin, D.Joe Anderson, Julie A. Trulson, Darren A. Thompson, Jill Wilken, Stephen B.H. Kent, Ira Gantz, Glenn L. Millhauser

Journal:

Year:

1999

Language:

english

File:

PDF, 507 KB

english, 1999

24

Agouti-related protein is a mediator of diabetic hyperphagia

Song-Yi Qu, Ying-Kui Yang, Ji-Yao Li, Qun Zeng, Ira Gantz

Journal:

Regulatory Peptides

Year:

2001

Language:

english

File:

PDF, 139 KB

english, 2001

25

Canine prosomatostatin: Isolation of a cDNA, regulation of gene expression, and characterization of post-translational processing intermediates

Chris J Dickinson, John DelValle, Andrea Todisco, Ira Gantz, Linda Tong, Susan Finniss, Tadataka Yamada

Journal:

Regulatory Peptides

Year:

1996

Language:

english

File:

PDF, 258 KB

english, 1996

26

Inverse agonist activity of agouti and agouti-related protein

Biao-Xin Chai, Richard R. Neubig, Glenn L. Millhauser, Darren A. Thompson, Pilgrim J. Jackson, Gregory S. Barsh, Chris J. Dickinson, Ji-Yao Li, Yu-Mei Lai, Ira Gantz

Journal:

Year:

2003

Language:

english

File:

PDF, 142 KB

english, 2003

27

The C-terminus of the third intracellular loop of the H2 receptor is important in the regulation of c-fos and cell growth

Lidong Wang, Meizhi Wang, Kenneth Butler, Ira Gantz, Edward Grand, John Del Valle

Journal:

Gastroenterology

Year:

2000

Language:

english

File:

PDF, 186 KB

english, 2000

28

Characterization of Agouti-Related Protein Binding to Melanocortin Receptors

Yang, Ying-kui, Thompson, Darren A., Dickinson, Chris J., Wilken, Jill, Barsh, Greg S., Kent, Stephen B. H., Gantz, Ira

Journal:

Molecular Endocrinology

Year:

1999

Language:

english

File:

PDF, 352 KB

english, 1999

29

Receptor−Antagonist Interactions in the Complexes of Agouti and Agouti-Related Protein with Human Melanocortin 1 and 4 Receptors †,‡

Chai, Biao-Xin, Pogozheva, Irina D., Lai, Yu-Mei, Li, Ji-Yao, Neubig, Richard R., Mosberg, Henry I., Gantz, Ira

Journal:

Year:

2005

Language:

english

File:

PDF, 561 KB

english, 2005

30

Topographical modification of melanotropin peptide analogs with .beta.-methyltryptophan isomers at position 9 leads to differential potencies and prolonged biological activities

Haskell-Luevano, Carrie, Boteju, Lakmal W., Miwa, Hiroto, Dickinson, Chris, Gantz, Ira, Yamada, Tadataka, Hadley, Mac E., Hruby, Victor J.

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 1.72 MB

english, 1995

31

Interactions of Human Melanocortin 4 Receptor with Nonpeptide and Peptide Agonists †,‡

Pogozheva, Irina D., Chai, Biao-Xin, Lomize, Andrei L., Fong, Tung M., Weinberg, David H., Nargund, Ravi P., Mulholland, Michael W., Gantz, Ira, Mosberg, Henry I.

Journal:

Year:

2005

Language:

english

File:

PDF, 415 KB

english, 2005

32

Characterizations of the Unusual Dissociation Properties of Melanotropin Peptides from the Melanocortin Receptor, hMC1R

Haskell-Luevano, Carrie, Miwa, Hiroto, Dickinson, Chris, Hadley, Mac E., Hruby, Victor J., Yamada, Tadataka, Gantz, Ira

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 200 KB

english, 1996

33

The melanocortin system: Table 1.

Gantz, Ira, Fong, Tung M.

Journal:

AJP Endocrinology and Metabolism

Year:

2003

Language:

english

File:

PDF, 74 KB

english, 2003

34

Neuroendocrine Regulation by the Agouti/Agrp-Melanocortin System

Barsh, Greg, Gunn, Teresa, He, Lin, Wilson, Brent, Lu, Xinyun, Gantz, Ira, Watson, Stanley

Journal:

Endocrine Research

Year:

2000

Language:

english

File:

PDF, 46 KB

english, 2000

35

A Survey of Patient Preferences for Oral Antihyperglycemic Therapy in Patients with Type 2 Diabetes Mellitus

Hauber, A. Brett, Tunceli, Kaan, Yang, Jui-Chen, Gantz, Ira, Brodovicz, Kimberly G., Alexander, Charles M., Davies, Michael J., Radican, Larry

Journal:

Diabetes Therapy

Year:

2015

Language:

english

File:

PDF, 1.72 MB

english, 2015

36

Molecular Cloning of a Gene Encoding the Histamine H2 Receptor

Ira Gantz, Matthias Schaffer, John DelValle, Craig Logsdon, Virginia Campbell, Michael Uhler and Tadataka Yamada

Journal:

Proceedings of the National Academy of Sciences

Year:

1991

Language:

english

File:

PDF, 966 KB

english, 1991

37

Agouti-Related Protein-Like Immunoreactivity: Characterization of Release from Hypothalamic Tissue and Presence in Serum 1

Li, Ji-Yao, Finniss, Susan, Yang, Ying-Kui, Zeng, Qun, Qu, Song-Yi, Barsh, Greg, Dickinson, Chris, Gantz, Ira

Journal:

Year:

2000

File:

PDF, 283 KB

2000

38

Agouti-Related Protein-Like Immunoreactivity: Characterization of Release from Hypothalamic Tissue and Presence in Serum 1

Li, Ji-Yao, Finniss, Susan, Yang, Ying-Kui, Zeng, Qun, Qu, Song-Yi, Barsh, Greg, Dickinson, Chris, Gantz, Ira

Journal:

Year:

2000

Language:

english

File:

PDF, 283 KB

english, 2000

39

Efficacy and Safety of Intranasal Peptide YY 3–36 for Weight Reduction in Obese Adults

Gantz, Ira, Erondu, Ngozi, Mallick, Madhuja, Musser, Bret, Krishna, Rajesh, Tanaka, Wesley K., Snyder, Karen, Stevens, Cathy, Stroh, Mark A., Zhu, Haiyuan, Wagner, John A., MacNeil, Douglas J., Heymsf

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

2007

Language:

english

File:

PDF, 119 KB

english, 2007

40

Effects of Recombinant Agouti-Signaling Protein on Melanocortin Action

Yang, Ying-Kui, Ollmann, Michael M., Wilson, Brent D., Dickinson, Chris, Yamada, Tadataka, Barsh, Gregory S., Gantz, Ira

Journal:

Molecular Endocrinology

Year:

1997

Language:

english

File:

PDF, 90 KB

english, 1997

41

Physiological and Anatomical Circuitry between Agouti-Related Protein and Leptin Signaling 1

Wilson, Brent D., Bagnol, Didier, Kaelin, Christopher B., Ollmann, Michael M., Gantz, Ira, Watson, Stanley J., Barsh, Gregory S.

Journal:

Year:

1999

Language:

english

File:

PDF, 897 KB

english, 1999

42

Naturally Occurring Mutations in the Melanocortin Receptor 3 Gene Are Not Associated with Type 2 Diabetes Mellitus in French Caucasians 1

Hani, El Habib, Dupont, Sophie, Durand, Emmanuelle, Dina, Christian, Gallina, Sophie, Gantz, Ira, Froguel, Philippe

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

2001

Language:

english

File:

PDF, 105 KB

english, 2001

43

The Human Gastrin/Cholecystokinin Type B Receptor Gene: Alternative Splice Donor Site in Exon 4 Generates Two Variant mRNAs

Il Song, David R. Brown, Rodney N. Wiltshire, Ira Gantz, Jeffrey M. Trent and Tadataka Yamada

Journal:

Proceedings of the National Academy of Sciences

Year:

1993

Language:

english

File:

PDF, 1.06 MB

english, 1993

44

Correction: Molecular Cloning of a Gene Encoding the Histamine H2 Receptor

Ira Gantz, Matthias Schaffer, John DelValle, Craig Logsdon, Virginia Campbell, Michael Uhler and Tadataka Yamada

Journal:

Proceedings of the National Academy of Sciences

Year:

1991

Language:

english

File:

PDF, 313 KB

english, 1991

45

A randomized clinical trial evaluating the safety and efficacy of sitagliptin added to the combination of sulfonylurea and metformin in patients with type 2 diabetes mellitus and inadequate glycemic control

Moses, Robert G., Round, Elizabeth, Shentu, Yue, Golm, Gregory T., O'neill, Edward A., Gantz, Ira, Engel, Samuel S., Kaufman, Keith D., Goldstein, Barry J.

Journal:

Journal of Diabetes

Year:

2015

Language:

english

File:

PDF, 666 KB

english, 2015

46

Molecular cloning, expression, and gene localization of a fourth melanocortin receptor

Gantz, Ira, Miwa, Hiroto, Konda, Yoshitaka, Shimoto, Yoshimasa, Tashiro, Takao, Watson, Stanley J., DelValle, John, Yamada, Tadataka

Journal:

Journal of Biological Chemistry

Year:

1993

Language:

english

File:

PDF, 1.40 MB

english, 1993

47

Molecular cloning of a novel melanocortin receptor

Gantz, Ira, Konda, Yoshitaka, Tashiro, Takao, Shimoto, Yoshimasa, Miwa, Hiroto, Munzer, Gerd, Watson, Stanley J., DelValle, John, Yamada, Tadataka

Journal:

Journal of Biological Chemistry

Year:

1993

Language:

english

File:

PDF, 2.58 MB

english, 1993

48

A randomized, placebo- and sitagliptin-controlled trial of the safety and efficacy of omarigliptin, a once-weekly DPP-4 inhibitor, in Japanese patients with type 2 diabetes

Gantz, Ira, Okamoto, Taro, Ito, Yuka, Okuyama, Kotoba, O'Neill, Edward A, Kaufman, Keith D., Engel, Samuel S, Lai, Eseng

Journal:

Diabetes, Obesity and Metabolism

Year:

2017

Language:

english

File:

PDF, 1.18 MB

english, 2017

49

A randomised, double-blind, trial of the safety and efficacy of omarigliptin (a once-weekly DPP-4 inhibitor) in subjects with type 2 diabetes and renal impairment

Chacra, Antonio, Gantz, Ira, Mendizabal, Geraldine, Durlach, Lucila, O'Neill, Edward A., Zimmer, Zachary, Suryawanshi, Shailaja, Engel, Samuel S., Lai, Eseng

Journal:

International Journal of Clinical Practice

Year:

2017

Language:

english

File:

PDF, 673 KB

english, 2017

50

A randomized clinical trial evaluating the efficacy and safety of the once-weekly dipeptidyl peptidase-4 inhibitor omarigliptin in patients with type 2 diabetes inadequately controlled on metformin monotherapy

Shankar, R. Ravi, Inzucchi, Silvio E., Scarabello, Victoria, Gantz, Ira, Kaufman, Keith D., Lai, Eseng, Ceesay, Paulette, Suryawanshi, Shailaja, Engel, Samuel S.

Journal:

Current Medical Research and Opinion

Year:

2017

Language:

english

File:

PDF, 1.13 MB

english, 2017

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